Grammy-winning singer Lizzo recently opened up about her weight loss transformation, revealing she tried Ozempic and other GLP-1 medications but ultimately found they weren’t the most effective solution for her goals. Instead, Lizzo emphasized how heavily processed vegan “junk food,” including imitation meats, slowed her progress.

Ozempic (semaglutide) is a GLP-1 receptor agonist drug originally approved by the FDA in December 2017 to treat type 2 diabetes. In 2021, the FDA approved a higher-dose version specifically for chronic weight management under the brand name Wegovy. Since then, Ozempic and Wegovy have become widely used to help people reduce appetite, leading to significant weight loss in many cases. Clinical trials show patients on these medications can lose on average 15-20% of their body weight over 68 weeks when combined with lifestyle changes.

Lizzo explained on the Just Trish podcast that Ozempic works by reducing appetite and helping users feel full faster, but she found that “mind over matter” and changing her diet yielded better results for her.

“Ozempic works because you eat less food, yeah? So if you eat right, it makes you feel full. But if you can just do that on your own and get mind over matter, it’s the same thing,” she said.

The major shift in Lizzo’s journey came when she stopped relying on processed vegan products like fake meats, bread, and rice.

“When I was vegan, I was consuming a lot of fake meats, I was eating a lot of bread, I was eating a lot of rice and I had to eat a lot of it to stay full,” she said.

It’s important to note that processed imitation meats are still processed foods—often high in sodium, refined carbs, and unhealthy fats—meaning they can be just as much “junk food” as non-vegan processed snacks.

Lizzo’s experience highlights a common misconception: being vegan or plant-based does not automatically mean eating healthy or feeling satisfied with smaller portions. The quality of foods matters more than labels. Choosing whole foods like vegetables, legumes, nuts, and whole grains, and understanding the difference between refined white rice and more nutrient-dense options like brown rice or quinoa, can significantly affect fullness and nutrition.

She said that after reintroducing whole foods such as beef, chicken, and fish, she felt genuinely full and was able to better control her intake naturally.

“When I started actually eating whole foods… I was actually full and not expanding my stomach by putting a lot of fake things in there that wasn’t actually filling me up,” Lizzo explained.

While some may criticize those who use weight loss medications like Ozempic, Lizzo urged empathy and understanding.

“It’s not easy… It’s a drug to help somebody with something they’re struggling with,” she said.

Her story offers a balanced view: medications can support weight loss, but lasting success comes down to food quality, sustainable habits, and self-awareness—not quick fixes or diet labels.

Raph_PH, CC BY 2.0, via Wikimedia Commons

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